Perioperative single dose antibiotic therapy in elective surgery

ABSTRACT

A placebo controlled study was undertaken to evaluate the role of antimicrobials as a single 24 hours cover peri-operatively. Patients matching in proposed surgery, age, sex, diagnosis and built were divided into three groups. Group 'A' was on placebo, group 'B' received full dose of antibiotics by conventional method and group 'C' received antibiotics as a single 24 hour cover perioperatively. The post operative incidence of complications was 27% in placebo, 13% in group 'B' and 7% in group 'C'. The perioperative use of antibiotics has been found to be comparatively more effective, safe and economical