Decalin-induced nephrotoxicity consequent to ovariectomy in female Rat

ABSTRACT

The aim of the present work was to test the influence of ovariectomy on the development of decalin kidney damage in female rats. A total of 60 female rats was used in this study and divided into three equal groups. Ovariectomy was done only to one group, treatment of an oral administration of decalin over a period of 12 days was given to this group and the other group, while the last group served as a control. Light and electron microscopic consequences of this treatment were examined by the end of the experiment. The results exhibited a destruction of the renal proximal convoluted tubules epithelium, which was mainly in the form of hyaline degeneration. It was suggested that the female rat kidney, which has been claimed not to suffer from exposure to decalin, was vulnerable to the damaging effect of decalin after ovariectomy. The reason for this change may be that the ovarian hormones can offer a protection against the toxic effect of decalin