Oral administration of calcium pectinate beads: study of resistance of digestive system at mouse

ABSTRACT

The controlled pharmaceutical forms, which include pharmaceutical vectors, have not been restricted to vascular, external or respiratory use, but they became useful for digestive system for the treatment of many diseases [1, 4, 15]. That due is to the great advantages of this via system. In this research, we studied the fate of pectin beads after their oral administration to a mouse. Design and Various forms of pectin were used to prepare beads in the presence of calcium ions to obtain egg- box model [2, 20]. This technique has enabled to get beads, which can carry the used active substances into the colon level, after they were coated with a protective material against gastrointestinal effects. 1- Pectin beads with dimensions 900- 1200 microm, were prepared using 6% of calcium ions [w/v]. They had a different swelling time and a good stability [80- 90%] in the gastrointestinal medium. Also they had an ability to release their contained active substance after three hours of their oral administration into studied mouse. 2- Time of active substance release from pectin beads was controlled into five different areas of digestive system of mouse. Also the fate of pectin beads was studied