Markers of cardiovascular disease in women with subclinical hypothyroidism

ABSTRACT

The relationship between sublinical hypothyroidism and astherogenic lipid profile is still controversial. This study evaluate some of the risk markers of cardiovascular disease in a group of women with subclinical hypothroidism, including biochemical and inflammatory markers as well as echocardiographic study. Twenty-three patients were compared with thirteen euothyriod. TSH, FT4, FT3, total cholesterol, low- density lipoprotein, high- density lipoprotein, triglycerides, CRP and IL-6 were done as well as echocardiographic examination.Significant increase in total cholesterol [P < 0.01], LDL-c [P < 0.01] and TG [P=0.0025] in subclinical hypothyroidism [SCH] patients versus control group. CRP and IL-6 were positively correlated with abnor malities in LV morphology and mass in SCH versus control group. A significant, diastolic dysfunction indicated by Significant. Prolongation of the isovolumic relaxation time [P < 0.001] and Significant. Reduction of the early diastolic mitral flow velocity/ late diastolic mitral flow velocity ratio [P < 0.001]. Serum total cholesterol, low- density liporpotein cholesterol, triglycerides, CRP and IL-6 are increase in women with subclinical hypothyroidism. Echocardiographic findings suggest that subclinical hypothyrodism causes diastolic dysfunction