Recent advances in anti-infectious chemotherapy: ertapenem, voriconazole, malarone

ABSTRACT

To assess the current knowledge of the clinical uses of ertapenem voriconazole and malarone, we explored articles published in the scientific literature. A benefit from ertapenem is documented in postsurgical abdominal infections including gynecological surgery. Ertapenem covers a wide spectrum of pathogens including anaerobes better than ceftriaxone and requires a lower number of injections compared to piperacillin-tazobactam. It should not be used in hospital acquired infections. Its use in community-acquired pneumonia is limited. Voriconazole shows favorable in vitro activity against yeasts including Cryptococcus spp, dimorphic fungi and several molds. Zygomycetes require considerably high MICs, It has less toxic effects such as infusion- related reactions and kidney damage, although more episodes of hallucinations have been observed. Malarone [atovaquone plus proguanil] is an Option for treatment and prophylaxis of malaria but routine use is not recommended. No clear superiority exists among the available regimens