Effect of diazinon and / or praziquantel on selected protein aspects in healthy and Schistosoma mansoni infected mice

ABSTRACT

The effect of 1/20 LD50 diazinon given orally to healthy and Schistosomiasis mansoni infected mice for 5-9 successive days and 17 weeks coupled with a therapeutic dose [2x500 mg/kg b. Wt.] of praziquantel two weeks before sacrificing. The results showed insignificant differences obtained from total proteins, albumin, globulins and albumin/globulin ratio. However, significant differences were revealed from alpha 1, alpha 2, beta 1, beta 2 and gamma-globulins in addition to plasma ceruloplasmin. Diazinon changed the levels of alpha 2, beta 1 and gamma-globulins, while diazinon coupled with schistosomiasis affected the levels of most of the studies parameters