Biochemical changes after subchronic and chronic interaction of Schistosoma mansoni infection in Swiss albino mice with two specific compounds

ABSTRACT

The effects of diazinon [DZN] and/or praziquantel [PZQ] on the levels of plasma triiodothyronine [T3] and thyroxine [T4], activities of brain acetylcholinesterase [AchE] and liver alanine aminotransferase [ALT] in addition to blood reduced glutathione [GSH] in healthy and Schistosoma mansoni [Sm] infected mice were investigated after 9 and 17 weeks of either infection or intoxication with DZN. Triiodothyronine showed significant differences among the different treatments. The group of mice treated with PZQ showed the highest levels of T3 at both time intervals. Thyroxine level showed significant differences between the two time intervals. The lowest levels of T4 were observed in the infected-PZQ grown at week 17. The maximum inhibition of brain AchE activity was noticed in DZN-PZQ treated group after 9 and 17 weeks