Effect of aspirin and nicotinic acid derivative as potential hypocholesterolemic agents

ABSTRACT

An increase in fat enriched diet may lead to higher accumulation of lipid, lipoprotein and cholesterol, which in turn may lead to cardiovascular complications. Several lines of evidence suggest that coronary heart diseases and atherogenesis are more directly related to different classes of hyperlipidemia. During the course of present project attempt is made to study the effect of aspirin and a nicotinic acid derivative as antihyper-cholesterolesteroiemic agents. Male white rabbits were fed for 120 days on diets comprising of cholesterol 200 mg/day plus butter 2 g/day. Concentration of cholesterol is determined and compared with that of the blood serum of control and experimental animals to evaluate the effect of aspirin and nicotinic acid derivative. This is evident from the results that these agents appreciably reduced blood cholesterol level