Regression of left ventricular hypertrophy after successful renal transplantation among uremic patients

ABSTRACT

Recognition of the natural history and responsible leading factors for regression of left ventricular hypertrophy after successful renal transplantation are very important. The aim of this study was to assess the regression of left ventricular hypertrophy after successful renal transplantation among uremic patients. In this study 27 uremic patients [18 males and 9 females] with an average age of 38.5 years were randomly selected. Left ventricular mass index [LVMI] was calculated before and after renal transplantation at the beginning, and at 4, 6 and 8 months. The means of LVMI before and after transplantation were 180 +/- 19.3 g/m[2] and 133.8 +/- 16.8 g/m [2] respectively [p<0.001]. The means of regression after transplantation at 0, 4, 6 and 8 months of follow up were 191g/m[2], 157.3 g/m[2], 147.8 g/m[2] and 138.8 g/m[2] respectively. There was a significant difference between the means of hemoglobin concentration and blood pressure before and after transplantation [p<0.001]. For instance the means of hemoglobin concentration and blood pressure was 7.2 +/- 0.4 and 13.1 +/- 0.7 g/dL, 154 +/- 6 / 97 +/- 4.4, and 135 +/- 6.3/ 89 +/- 3.8 mmHg respectively. This study showed that maximum left ventricular hypertrophy regression occurred 4 months after transplantation, then decreased to a minimum level of 147.8 and 135.8 g/m[2] at 6 and 8 months after transplantation respectively. Restoration of hemoglobin concentration and blood pressure to normal levels may be recognized as a main cause of left ventricular hypertrophy regression