Hypercoagulable state in children with nephrotic syndrome: a study of some markers of hemostasis activation

ABSTRACT

This study included 50 children with nephrotic syndrome; 28 were in relapse [group I] and 22 were in therapy withdrawal after successful remission [group II]. Twenty healthy children were included as controls. Thrombin antithrombin complex [TAT], fibrin monomer [FM], plasma fibrinogen, alpha-2-antiplasmin [alpha-2AP] tests and platelet counts were performed to detect the coagulation anomalies that are suggestive of a hypercoagulable state in the nephrotic cases. Serum albumin, total cholesterol and triglycerides levels were also determined. In conclusion, data suggested the presence of a prethrombotic state in the nephrotic cases, particularly in the relapse group. Elevated TAT, FM as well as fibrinogen and platelet count seem to be reliable indicators of this prethrombotic state. A significant reduction in the anti-fibrinolytic marker alpha-2AP was detected in the plasma of relapsing nephrotic cases