Prevalence of H.influenzae biotypes and their clinical significance in a University Hospital
Saudi Medical Journal. 2003; 24 (12): 1308-12
en Inglés
| IMEMR
| ID: emr-64501
ABSTRACT
Hemophilus influenzae is an important pathogen that is responsible for invasive and non-invasive infections in both children and adults. This study aims to assess the relationship of biotypes to the sites of infection, serotypes, antimicrobial susceptibility, b-lactamase production and age. A total of 200 isolates of H.influenzae were obtained from clinical specimens over a period of 12 months from January 2001 through to January 2002 from King Abdul-Aziz University Hospital, Riyadh, Kingdom of Saudi Arabia. Most of the strains were non-typable and were isolated from patients with non-invasive infections. The typable isolates from invasive infections mostly serotype b were isolated from blood, cerebrospinal fluid and hip joint aspirate. Biotype II accounted for 37% of the isolates followed by biotypes III and I [29.5% and 23%]. The remaining 10.5% were made up of biotypes IV, V, VI and VII. A significantly high resistance to cotrimoxazole [33.5%] and ampicillin [19%] was observed. Two point five% of the isolates were resistant to chloramphenicol. All the isolates resistant to ampicillin were b-lactamase producers and susceptible to cefuroxime, ceftriaxone, ciprofloxacin and rifampicin. This study revealed that biotypes II and III are the predominant biotypes of H.influenzae found in non-invasive infections. There is an apparent relationship between biotype and site of infection which could be useful as an epidemiological marker
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Beta-Lactamasas
/
Farmacorresistencia Microbiana
/
Pruebas de Sensibilidad Microbiana
/
Prevalencia
/
Técnicas de Tipificación Bacteriana
/
Hospitales Universitarios
Tipo de estudio:
Estudio de prevalencia
Límite:
Humanos
Idioma:
Inglés
Revista:
Saudi Med. J.
Año:
2003
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