Distribution of arylamine N acetyltransferase 2 [NAT2] genotypes among Omanis

To determine the genotypes of arylamine N-acetyltransferase [NAT2] among 127 unrelated apparently healthy Omanis. Identify the most common known polymorphisms of NAT*2 gene namely, G191A, C282T, C341T, C481T, G590A, A803G and G857A using PCR-RFLP analysis. Eleven allele variants [3 alternative] and 30 different genotypes were determined. The commonest alleles were found to be NAT*5B, NAT2*6A and NAT*4 with corresponding frequencies of 0.362, 0.248 and 0.189 respectively. The overall frequency of rapid acetylator alleles was 0.25. A new allele variant containing G590A, C282T and T341C polymorphisms was found in one subject [was named NAT2*5J]. The commonest genotypes were found to be 5B/5B, 5B/6A, 4/5B, 4/6A with frequencies 0.165, 0.157, 0.118, 0.110 and 0.079 respectively