Promoting effects of carnosine on serum proteins in normal and partially hepatectomized mice

ABSTRACT

The effect of carnosine administration for 15 and 30 days on 13 different serum proteins, total protein, albumin, prealbumin, alpha-and beta-lipoproteins, alpha-1-macroglobulin, alpha-1 acid glycoprotein, alpha-1 antitrypsin, cholinesterase, ceruloplasmin, hemopexin, haptoglobin and transferrin and 3 liver parameters [DNA, RNA and weight] were investigated in healthy [HC] and partially hepatectomized [PHC] mice. HC15 days animals presented 4 increased parameters, while the PHCl5 days mice presented 11 promoted parameters. In 30 days groups, HC30 days mice demonstrated increased 13 parameters, while the PHC30 days showed promotion of all parameters. These results pointed to the protein promoting effect of carnosine in both normal and partially hepatectomized mice. However, the more actively regenerating liver cells in the operated mice were more labile to stimulation by carnosine administration