use of new markers for the detection of liver damage in experimental rats administered certain heavy metals

ABSTRACT

Pollution either environmental or industrial becomes one of the most serious problems in this century. In a previous research dealing with the same subject, groups of male healthy workers were selected and recruited from some industrial locations [melting units of different metal factories]. Certain parameters were determined and the results obtained revealed that, neither serum liver enzymes, nor heavy metals level recorded any alterations. Fibronectin and chondroitin sulfate on the other hand, demonstrated significant increase which may be considered as an early marker for liver cirrhosis which may happen later on. The present work was suggested using experimental animals, which received the same heavy metals [Fe, Cu and Pb] for Certain periods aiming to support and confirm the previously observed clinical findings through the examination of liver tissues histopathologically