Effect of permethrin on the experimentally induced diabetes and on its management with some antidiabetic drugs

ABSTRACT

The aim of the present work was to study the influence of permethrin [a synthetic pyrithroid insecticide] on the experimentally induced diabetes and on the antidiabetic effects of some may be faced by man, as it is equivalent to 10 times, the acceptable daily intake. Male Albino rats were divided into 2 main groups, control group [fed normal diet] and permethrin treated group [fed diet containing 21.7 ppm, permethrin] for 30 days. At the day 31, the animals of each group were subdivided to 8 groups as following 1- No further treatment. 2- Treatment by insulin [10M U/100gm S.C.]. 3- Treatment by glibenclamide [0.5 mg/kg, orally]. 4- Treatment by metformin [71.4 mg/kg. Orally] 5- Treatment by alloxan [120 mg/kg, S.C.]. 6- Treatment by alloxan + insulin. 7- Treatment by alloxan + glibenclamide. 8- Treatment by alloxan + metformin. The obtained results regarding blood glucose level showed that 1- Permethrin increased blood glucose level by 17.882%. 2- In normally fed groups [control], insulin and glibenclamide reduced the blood glucose level by 58.078% and 73.496%, respectively while metformin showed no effects 3- In permethrin treated groups, insulin and glibenclamide reduced the blood glucose level by 32.768% and 79.871%, respectively, while metformin slightly increased this level by 5.510%. 4- Alloxan induced increase in blood glucose levels by 88.435% and 69.154% in control and permethrin treated animals. 5- In case of experimentally induced diabetes, both insulin and glibenclamide, caused an equal decrease of glucose level in control and permethrin treated animals. On the other hand metformin induced a decrease in blood glucose level of normally fed animals but not in permethrin treated animals