Autoantibodies in HCV infected patients at Sharkia Governerate, Egypt
Journal of the Egyptian Society of Parasitology. 2004; 34 (1): 429-45
en Inglés
| IMEMR
| ID: emr-66738
ABSTRACT
The aim of this study was to evaluate some immunological manifestations in chronic hepatitis C patients and to find out its relationship with liver pathology. The study included 109 positive HCV-RNA patients classified according to liver histopathology into three groups Group I included 22 patients [G1S1], group II included 67 patients [G2S2] and group III included 20 patients [G3S3], where G = the degree of necro-inflammatory process and S = the stage of liver fibrosis. All patients were investigated for the presence of cryoglobulin, antineutrophil cytoplasmic [ANCA], anti-liver kidney microsomes [LKM], anti-double stranded DNA, [ds-DNA], anti-nuclear [ANA], anti-mitochondrial [AMA] and anti-smooth muscle [ASMA] autoantibodies. The high prevalence of autoantibodies in chronic HCV patients suggests that HCV may trigger an autoimmune reaction, but most probably do not indicate a distinct autoimmune mechanism. Cryoglobulins and ANCA may be considered as useful prognostic indicator for the increased risk of cirrhosis in chronic HCV patients. Follow up studies were recommended
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Autoanticuerpos
/
Anticuerpos Antinucleares
/
Hepatitis C
/
Técnica del Anticuerpo Fluorescente Indirecta
/
Crioglobulinemia
/
Hígado
/
Pruebas de Función Hepática
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
J. Egypt. Soc. Parasitol.
Año:
2004
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