Study of XmnI polymorphism in 5 region of the apoAl gene in Iranian hyperlipidemic subjects
KOOMESH-Journal of Semnan University of Medical Sciences. 2004; 6 (1): 63-67
en Persa
| IMEMR
| ID: emr-67252
ABSTRACT
Several studies have demonstrated the relationship between polymorphisms in the ApoAl - CIH - AIV gene cluster and hyperlipidemia. This study was conducted to elucidate the association between polymorphism of ApoAI/XmnI and Iranian hyperlipidemic subjects. Total genomic DNA was prepared from seventy-six Iranian patient with primary hyperlipidemia and seventy-five normolipidemic subjects. The subjects in the control group were age-and sex-matched to the patients. Fragment of 392 bp for 5 region of the apoAl gene [C-2500T] was amplified by polymerase chain reaction [PCR]. In the hyperlipidemic group, the genotype frequency of X1X1, X1X2, X2X2 were 0.63, 0.24, 0.13, respectively. In the control group those were 0.81, 0.11 and 0.08, respectivley. There was a significant difference [p<0.05] between 2 groups. The rare allele [X2] was more frequent in hyperlipidemic group than in controls [p<0.01]. Various genotypes of apoAl/Xmnl had no significant effect on lipids or apoAI levels in hyperlipidemic group. The above results show that polymorphism ApoAl/XmnI is associated with hyperlipidemia in Iranian hyperlipidemic subjects. Therefore, our data confirmed the previously reported association between genetic polymorphism ApoAI/XmnI and hyperlipidemia
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Apolipoproteína A-I
/
Hiperlipidemias
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Persa
Revista:
KOOMESH-J. Semnan Univ. Med. Sci.
Año:
2004
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