Serum carboxy terminal telopeptide of type 1 collagen as a marker of bone metastasis from lung cancer

ABSTRACT

In this study, carboxy-terminal telopeptide of type I collagen [ICTP] was measured in both metastatic as well as non-metastatic bronchogenic carcinoma patients and it was compared with a group of normal controls. The serum level of ICTP was significantly higher in the metastatic as well as non-metastatic groups of patients compared with the control group. It was also higher in metastatic group when compared with the non-metastatic one. It was found that at a cut off value of 5.5 mu/l of ICTP, the diagnostic sensitivity was 96.2%, specificity was 86.6% and accuracy was 92.8%