Role of interferon-alpha, interleukin-1 beta and T cell activation in aplastic anemia pathogenesis
Medical Journal of Cairo University [The]. 2004; 72 (1): 59-64
en Inglés
| IMEMR
| ID: emr-67563
ABSTRACT
The present work was performed to clarify the role of stimulatory cytokine as IL-1 beta and inhibitory cytokine as IFN-gamma and T cell activation evidenced by CD25 expression in the pathogenesis of aplastic anemia. Twenty-eight newly diagnosed aplastic anemia patients and 15 age and sex matched healthy controls were included in this study. An estimation of IL-1 beta, IFN-gamma and the percentage of CD25 expression was done to all patients and controls. IFN-gamma was significantly higher in AA patients as compared with the age matched controls. IL-1 beta was significantly lower in AA patients as compared with the controls. The percentage of CD25 expression was significantly higher in AA patients as compared with the controls. There was a highly positive significant correlation between IFN-gamma and leucocytopenia. There was a negative significant correlation between IL-1 beta and each of age and leucocytopenia. There was a highly positive correlation between CD25 expression and Hb level of the patients
Buscar en Google
Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Receptores de Interleucina-2
/
Interferón gamma
/
Interleucina-1
/
Índices de Eritrocitos
/
Citometría de Flujo
/
Anemia Aplásica
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Med. J. Cairo Univ.
Año:
2004
Similares
MEDLINE
...
LILACS
LIS