Strong Association of HMB - 45 expression with renal angiomyolipoma
Saudi Medical Journal. 2004; 25 (8): 1020-1023
en Inglés
| IMEMR
| ID: emr-68795
ABSTRACT
Angiomyolipoma [AML] is a benign neoplasm consisting of varying mixtures of smooth muscle, blood vessels and fat. Although, most of these tumors are easy to recognize, some may pose a diagnostic dilemma due to unusual histologic features. Recently, it was suggested that melanosome-associated protein [HMB-45] immunoreactivity may be used for diagnostic confirmation of several neoplasm. The aim of this study is to analyze the diagnostic efficacy of HMB-45 in patients with AML. This study was carried out at the Faculty of Medicine, Department of Pathology, Dicle University, Diyarbakir, Turkey, during the period January 2000 to September 2003. HMB-45 immunoreactivity was analyzed in 6 patients with AML and in 34 patients with other renal and retroperitoneal pathologies, including 10 nephrectomized patients for non-neoplastic reasons by means of immunohistochemistry. Patients with AML were positive for HMB-45. Whereas, HMB-45 immunoreactivity was negative in all of the histologic specimens from the patients with renal cell carcinoma, retroperitoneal sarcomas, Wilms' tumor, lipoma, leiomyoma, and nephrectomized kidneys of non-neoplastic reason. The association of AML with HMB-45 immunoreactivity was highly significant [p<0.001]. Our findings suggest that HMB-45 may not be a melanocyte-restricted marker, and can be useful in differential diagnosis between AML and other tumors seen in kidney and retroperitoneal region
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Inmunohistoquímica
/
Tumor de Wilms
/
Melanosomas
/
Neoplasias Renales
/
Liposarcoma
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Saudi Med. J.
Año:
2004
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