Pathogenie de l'hepatite auto-immune
Tunisie Medicale [La]. 2004; 82 (9): 799-804
en Francés
| IMEMR
| ID: emr-69163
ABSTRACT
the aim of the study was to review the pathogenic mechanisms of auto-immune hepatitis. the study was based on a review of all relevant articles from literature on the mechanisms of auto-immunity in auto-immune hepatitis. the precise mechanisms through which liver damage occurs are not fully understood. Autoimmune hepatitis seems to be a consequence of auto-antigen exposure, genetic predisposition and defective immuregulatory mechanisms. Auto-antigen is presented by class II molecules of the major histocompatibility complex. Cytokines and non specific auto-immune promoters modulate immune reactivity. Cellmediated and antibody-dependent forms of cytotoxicity are probably interactive pathogenic mechanisms. disturbance in the tight balance between auto aggression and self-tolerance, affected by several internal and external factors are likely in auto-immune hepatitis
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Autoantígenos
/
Citocinas
/
Predisposición Genética a la Enfermedad
/
Hepatocitos
/
Antígenos
Límite:
Humanos
Idioma:
Francés
Revista:
Tunisie Med.
Año:
2004
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