Serum insulin like growth factor 1 and insulin like growth factor binding protein 1 in primary antiphospholipid syndrome

ABSTRACT

To study maternal serum concentrations of insulin growth factor [IGF-I] and insulin growth factor binding protein [IGFBP-1] in women with primary antiphospholipid syndrome [PAPS]. A prospective study. Hospital of Obstetrics and Gynecology, Ain Shams University. Ten women with Primary Antiphospholipid Syndrome [PAPS] and Ten normal pregnant women were included in this prospective study. The mean age for both groups did not show significant difference. Patients with PAPS delivered earlier and with a lower birth weight. The difference between both groups were significant for both gestational age at labor and birth weight [p<0.0001]. Serum IGF-1 was lower in PAPS than the control group throughout pregnancy. The level of IGF-1 decreased significantly in the PAPS group [p<0.0001]. The level of IGF-1 increased significantly in the control group late in pregnancy [p=0.0317]. Serum IGFBP-1 was higher in the PAPS group than the control group in early and late pregnancy [p<0.0001]. The level of IGFBP-1 increased significantly in the PAPS group and in the control group [p<0.0001]. Primary Antiphospholipid Syndrome [PAPS] is associated with a progressive decrease in the levels of serum IGF-1 during pregnancy. The levels of IGFBP-1 increased in all pregnant women but were higher in patients with Primary Antiphospholipid Syndrome [PAPS]