Dermatophytoses and the high level of CR3 [CD11b/CD18]

ABSTRACT

In patients infected with dermatophytoses there is a continuous fungal antigen shedding into the circulation, especially during chronic infection, including the cell wall component beta-glucan as one of the fungal antigen. CR3 [CD1lb/CD18] serves as a leukocyte receptor for particulate and soluble beta-glucan. The keratinocyte induction by the fungus; to produce certain cytokines and their role in the upregulation of CD11 b expression. All can explain our results with the high level of CD11b expression in of Cd D11b dermatophytic expression in patients in comparison to controls group, and in chronically infected patients more than in acutely infected patients