Synthesis and in vitro anticancer evaluation of some new [tetrahydronaphthalen-2y1] nitrogen heterocycles

ABSTRACT

Condensation of 2-acetyltetralin I with two aromatic aldehydes afforded the respective chalcones 7a,b. When the reaction of 1 with aldehydes was conducted in presence of ethylcyanoacetate and/or malononitrile and ammonium acetate, it yielded tetrahydronaphthalenyl nicotinonitriles of types 3 and 4. Chalcones 7a,b yielded 2-pyrimidinones 8a,b, 2- thiopyrimidines 9a,b and pyrazoline derivatives 10a,b upon reaction with urea, thiourea and hydrazine, respectively. Reaction of compound 5 with different amines gave the corresponding anilino-derivatives. Compounds 3a, 9a, 10a, 5, and 6b were evaluated for their anticancer activity