Effects of prostaglandins F2a on sperm cell characteristics and histopathological changes of testes and accessory genitalia in rats

ABSTRACT

Three hundred and thirty mature male albino rats were used for studying the effect of prostaglandins F[2] alpha on the sperm cell characteristics and the histopathological changes of their genital organs. Sperm cell concentration and their motility percentage were significantly increased in rats injected with 10 and 20 micro g PGF[2]a. The same parameters were decreased in rats injected with 75 and 125 micro g PGF[2]za. Activation of most of the seminiferous tubules and decrease in the secretions of the seminal vesicles and prostate were observed in rats subjected to 10 micro g of PGF [2]a. Higher doses 75 and 125 micro g PFG[2]a induced atrophy of the seminiferous tubules, hyperplasia of the epithelium lining the seminal vesicles and decrease of secretions in the prostate and seminal vesicles