Histo-pathological changes after exposure of rabbit to lead

Rabbits were immunized with ribosomal antigens prepared from E. coli and exposed to lead acetate. The histological picture of immunized animal showed immunological response to ribosomal antigens. Hyperplasia with the appearance of germinal centers was noted in lymph nodes and spleen in addition to infiltration of intestine with mononuclear cells. The pathological changes which appeared as a result of exposure to lead were represented by central venous and sinusoidal congestion in the capillary tuft of glomeruli and also in the vessels between proximal convoluted tubules. While in the brain, there was congestion and edema. It is concluded that the effect of lead on the body persists for long time after stoppage of lead exposure, and produced disturbances in immune system