Synthesis of some pyridazinyl acid derivatives

ABSTRACT

In a previous report we studied the thione-thiol tautomerism in 6-arylpyridazin-3 [2H]-thiones and came to the conclusion that these compounds exist mainly, if not entirely in the thione form. However the reacting tautomer of these compounds was found to depend upon the reaction medium. In continuation to this study, this report deals with the reaction of 6-arylpyridazin-3 [2H]-thiones with ethyl bromoacetate and acrylonitrile as a simple route for the synthesis of some pyridazinyl acid derivatives of expected biological activity