Hepatoprotective effect of silybum marianum [L] gaertn and glycyrrhiza glabra L. in the rats

ABSTRACT

One of the major role of liver is metabolism of xenobiotics and detoxification. But sometimes during metabolism of xenobiotics produce active and more toxic agents which cause liver damage and disease. Use of nature products from vegetables. In the treatment of diseases and liver diseases have a long history, especially in Eastern medicine in this study we have investigate the protective effects of polyphenolic extracts of Silybum marianum and Cichorium intybus. Liver damage induced with hepatotoxin, thioacethamide. Extracts was injected every day for a duration of 3 days, to rats, at a doses of 25 mmg/kg body weight together with thioacetamide at a doses of 50 mg/kg body weight. In order to investigate the hepatoprotective effect of extracts against thioacetamide activities of serum aminotrasferases [SGOT and SGPT], alkalline Pbosphatase bilirubin, Na[+] and K[+] were measured.Activities of serum aminotrasferases [SGOT and SGPT], alkaline phosphatase and bilirubin were decreased significantly to rats treated with extracts compared to thioacetamide group. The results showed potent protective effects of these extracts against the thioacetamide induced hepatotoxicity that are due to antioxidant effect of polyphenolic compound