relationship between glucose 6-phosphate dehydrogenase deficiency and neonatal hyperblirubinemia

ABSTRACT

Studies have shown that G6PD deficiency results in indirect hyperbilirubinemia in newborns. Determining the relationship between G6PD deficiency and neonatal hyperbilirubinemia. Through a case-control study, 200 neonates with indirect hyperbilirubinemia were equally divided into two case and control groups and examined for G6PD deficiency using a commercial G6PD kit and a fluorometric analysis. The data were further analyzed statistically. Results showed that out of 200 neonates, 24 had G6PD deficiency [10 in case group and 14 in control group]. There was no statistically significant difference between two groups. Since the prevalence of G6PD deficiency among nonicteric group [control group] was higher than the icteric group [case group], it seems that the performance of a screening test to measure the G6PD activity in all neonates to be useful