Comparison of efficacy and safety of topical Ketotifen [Zaditen] with cromolyn sodium in the treatment of vernal keratoconjunctivitis
JRMS-Journal of Research in Medical Sciences. 2005; 10 (2): 87-92
en Inglés
| IMEMR
| ID: emr-72834
ABSTRACT
This study compared the efficacy of Ketotifen fumarate.025% [Zaditen] with Cromolyn sodium 4% [Opticrom] eye drops in prevention of itching, tearing, and redness in Vernal Keratoconjunctivitis [VKC]. This double blind randomized single center clinical trial conducted between April and August 2004 in Yazd. One hundred eligible patients with clinical diagnosis of moderate VKC were randomly prescribed Zaditen [group A n=50] and Cromolyn sodium [group B n=50] eye drops for a 4 weeks period. Itching, lacrimation, redness, and hotophobia were scored on a 4-points severity scale. After 7 days of treatment, the response rates based on subjects assessment of global efficacy was significantly greater in Ketotifen group [61.5%] than in Cromolyn group[53%].A clear response to treatment occurred in 94.4 of Zaditen and 81.2% of Sodium Cromoglycate treated patients. The investigator,s assessment of response rates also showed that Ketotifen was superior to Cromolyn sodium [P=0.001]. Ketotifen produced a significantly better outcome than Cromolyn for relief of signs and symptoms of VKC [P<0.05]. Ketotifen fumarate treatment significantly reduced the total signs and symptoms score for each patients, in compare with day 0. Ketotifen had a faster onset of action and provided better symptom relief than Cromolyn. The rapid onset of action and symptom control, make Zaditen a valuable treatment for VKC
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Soluciones Oftálmicas
/
Prurito
/
Lágrimas
/
Método Doble Ciego
/
Cromolin Sódico
/
Cetotifen
Tipo de estudio:
Ensayo Clínico Controlado
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
J. Res. Med. Sci.
Año:
2005
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