Association of helicobacter pylori infection with cardiac syndrome X

ABSTRACT

Cardiac syndrome X includes chest pain and positive exercise and /or radionuclide test and normal coronary angiography. There is no obvious etiology for this syndrome. Some mechanisms such as endothelial dysfunction and estrogen deficiency have been explained. In this study, we studied correlation between helicobacter pylori infection and cardiac syndrome X 23 patients [17 female and 6 male] with cardiac syndrome X between 30-65 years old [mean 42 +/- 4] matched with control group [16 female and 7 male] between 31-64 years old [mean 41 +/- 4]. Helicobacter pylori infection detected by urease breathe test [UBT]. Patients with dyspepsia and coronary spasm were excluded. UBT showed that 91% of cases in patient group and 48% in control group were positive for helicobacter pylori infection, and this difference was significant [P<0.001]. Due to high prevalence of infection with helicobacter pylori in cardiac syndrome X patients [91%] in comparison with it's prevalence in control group [48%], possibility of relationship between infection with helicobacter pylori and cardiac syndrome X is suggested