Correlation between HLA system and primary vesicoureteral reflux

The polygenic mode for inheritance of Vesicoureteral Reflux [VUR] is a debutable issue. Our study is aimed to investigate the correlation between HLA system and VUR. Materials: The study included thirty patients with VUR and sixty patients from kidney donors as control group. Initially the HLA formulas of each patient were detected according to racial-geographical distribution as well as common and specific antigens. Then, the Relative Risk [RR] for the class I antigens of the HLA system was calculated and the X2 statistical test was performed for the antigens with RR>1 to establish a significant association between HLA system and VUR. Result: Increased frequency of the genes HLA-A9, HLA-B44 were characterized by statistical analysis [RR>1, X2>3.84]. Therefore, the significant correlation was found between VUR and HLA system [P<0.05]. There are significant correlation between VUR and HLA-A9 and HLA-B44. However, more study is necessary so that these genes may become markers for VUR