Effect of some trace minerals on magnesium, zinc, lipid profile, liver function and kidney function in alloxan diabetic rats

ABSTRACT

The present work was conducted to study the beneficial effect of magnesium, zinc and their combinations on diabetic rats. In this study, we investigated the effects of two doses of magnesium sulfate, zinc chloride and their combinations on the nutritional value, percent of organs weight / body weight, serum [glucose, magnesium, zinc, cholesterol, triglycerides, kidney and liver functions] of diabetic rats. Sixty-four male Albino rats were divided into two main groups. The first main group [8 rats] fed on basal diet and was considered negative control. The second main group [56 rats] was injected with 150-mg / kg-body weight of recrystallized alloxan to induce hyperglycemia. Diabetic rats was randomly assigned to seven equal subgroups one of them left as positive control and the other six groups received a basal diet and treated daily orally with [1] 100 mg/kg body weight magnesium sulfate. [2] 200-mg/kg body weight magnesium sulfate. [3] 10 mg/kg body weight zinc chloride. [4] 20 mg/ kg body weight zinc chloride. [5] 100-mg/kg-body weight magnesium sulfate and 10-mg/ kg body weight zinc chloride. [6] 200-mg/kg-body weight magnesium sulfate and 20-mg/ kg body weight zinc chloride. Treating diabetic rats with low and high doses of magnesium, zinc or their combinations resulted in improvement of the nutritional value, in addition to the percent organs weight / body weight. The mean values of serum magnesium and zinc increased in most treated diabetic groups, while the levels of cholesterol, triglycerides, uric acid, urea nitrogen, aspartate amino transferase [AST] and alanine amino transferase [ALT] decreased in all treated groups especially with the high doses, as compared to the positive control groups. The results showed that the best effect on serum parameters in diabetic rats was with high doses of magnesium, zinc and their combinations