study of most sensitive double marker diagnostic method of creatine kinase- Mb, myoglobin and troponin I in acute myocardial infarction

ABSTRACT

Myocardial Infarction is the most frequent diagnosis in the admitted patients in Western Countries that is important to diagnose rapidly. This study was designed to determine the most sensitive double marker diagnostic method of Creatine kinase- Mb, myoglobin and troponin I in acute myocardial infarction. This descriptive diagnostic test study was performed on patients with cardiac angina that began between 4-24 hr without Ml history and didn't receive cardiac electroshock. Quota sampling was done on 256 emergency patients in two 4-14 hour and 15-24 hour after begin of pain group. Collected data analyzed with SPSS11.5 software. The most sensitive and specific double marker in the period was troponin l-Myoglobin [97.3%, 98.1%] and in the second period was creatine kinase- Mb-troponin I [100%, 96.3%]. The perfect method for the first period the combination of troponin l-Myoglobin and for the second period is double markers Creatine kinase- Mb-troponin I