Trial to increase the duration of neutralizing antibodies in cattle vaccinated with inactivated FMD vaccine

ABSTRACT

Inactivated FMD vaccine is weakly immunogenic and multiple vaccinations at four-month intervals are necessary for the prevention of the disease. Our results revealed that in cyclophosphamide treated animals, the antibody titers remained protecting up to 35 weeks post vaccination, while in non treated group, the animals became susceptible to infection 19 weeks post vaccination. So, it is possible to increase the duration of neutralizing antibodies in serum when a low single dose of cyclophosphamide is administered four days before vaccination with aluminum hydroxide-saponin FMD vaccine and this will increase the intervals between vaccinations and decrease the commercialization costs of vaccination programs