Outbreak of botulism type E associated with eating traditional soup in a family group, Loghman Hakim Hospital, Tehran, Iran

ABSTRACT

Botulism is a neuroparalytic illness caused by clostridium botulinium toxin that is usually transmitted as a foodborne disease. It is manifested by cranial nerve dysfunction and descending flaccid muscle paralysis. Patients Eleven members of a family developed severe weakness, lethargy and other clinical manifestations compatible with botulism following the ingestion of traditional soup. Stool, gastric fluid and serum samples were submitted for toxicological evaluation with standard mouse bioassay, while, only one patient demonstrated type E toxin. All patients received 3 monovalent antitoxins A, B and E, whilst most of their symptoms improved within 12 hours, This study confirmed that prompt administration of antitoxin could prevent progression of the disease and may be a life-saving approach. Keywords Botulism, Antitoxin, Outbreak