Your browser doesn't support javascript.
loading
[Experimental production and initial imaging of [18 F]-14-Fluoro-6-thia-hepatadecanoic acid [[18F]-FTHA] for myocardial performance]
Iranian Journal of Nuclear Medicine. 2006; 14 (26): 35-41
en Persa | IMEMR | ID: emr-77064
ABSTRACT
[18F]-6-thia-14-fluoro-heptadecanoic acid 3b, a free fatty acid, has been used in myocardial PET imaging. In order to establish an automated synthesis module for routine production in the country, a study performed for optimization of the production conditions as well as making modifications. [18F] Benzyl-14-Fluoro-6-thia-heptadecanoate 2b was prepared in no-carrier-added [n.c.a] form from C in Benzyl-14-tosyloxy-6-thia-heptadecanoate 1 in one step at 90 Kryptofix2.2.2/[18F] and acetonitrile as the solvent followed by Silica column chromatography. The radiolabeled ester 2 was then hydrolyzed to yield [18F]-6-thia-14-fluoro-heptadecanoic 3b. The final solution was concentrated using C18 SPE system and administered to normal rats for biodistribution as well as co-incidence imaging studies. The synthesis took 15 min with overall radiochemical yield of 15-25% [EOS] and chemical-radiochemical purity more than 94%. Automation was performed using a two-pot synthesis. The best imaging time was shown to be 140-180 minutes post injection. Using this procedure a fast, reliable, automated synthesis for the cordial PET tracer, i.e. [18F]-FTHA can be obtained without HPLC purification step
Asunto(s)
Buscar en Google
Índice: IMEMR (Mediterraneo Oriental) Asunto principal: Tomografía de Emisión de Positrones / Ácidos Grasos / Fluoruros / Miocardio Idioma: Persa Revista: Iran. J. Nucl. Med. Año: 2006

Similares

MEDLINE

...
LILACS

LIS

Buscar en Google
Índice: IMEMR (Mediterraneo Oriental) Asunto principal: Tomografía de Emisión de Positrones / Ácidos Grasos / Fluoruros / Miocardio Idioma: Persa Revista: Iran. J. Nucl. Med. Año: 2006