Biochemical and molecular studies on the hepatoprotective effect of ginger

ABSTRACT

The hepatoprotective effect of acetone soluble fraction [ASF] of petroleum ether extract of ginger was evaluated in vivo by using CC1[4] model, which induced hepatotoxicity. The results revealed that the activities of ALP, AST, ALT and TBARS were increased after adminsitraiton of CC1[4]. This effect of CC1[4] This effect of CCL[4] was attenuated by acetone soluble fraction of ginger by two doses. Also, lysosomal enzymes were markedly increased after administration of CC1[4], but this effect was ameliorated by ASF of ginger nearly to the control group. These results demonstrate that acetone soluble fraction of ginger plant exerted a hepatoprotective activity in vitro and in vivo and may be useful in the treatment of hepatotoxicity and liver diseases