Influence of imiprothrin and diflubenzuron on an atopic disease model induced by bordetella pertussis and hiberix vaccines in mice

ABSTRACT

Atopic diseases seemed to merge as a dramatic clinical problem especially in developing and poor countries. This work aimed to study the possible influence of the insecticides imiprotherin and difubenzuron on the atopic phenomenon induced by Bordetella pertusis [B-p] and Hiberix vaccines. Swiss albino mice were fed on insecticide free diet, imiprothrin or difubenzuron containing diet. The insecticide concentrations were ten times the acceptable daily intake given for four weeks. Animals were vaccinated either with B-p. or Hiberix vaccines in single or repeated doses and blood eosinophil counts were then determined. The results revealed that - Severe eosinopenia appeared in animals fed by diet containing imiprotherin or diflubenzuron compared with animals fed by insecticide free diet [before vaccination]. - Single or repeated vaccination with either B-p or Hiberix induced a phase of eosinopenia followed by an eosinophilic phase in animals fed insecticides free diet. - Single or repeated vaccination with either B-p or Hiberix induced continuous phase of eosinophilia in animals fed imiprothrin or diflubenzuron containing diet, which was more potentiated compared with control group. - The onset of eosinophilia starts first day after vaccination