Histological alterations in the liver of mother rats and its weanlings fed on fried bread and the protective effect of curcumin

ABSTRACT

This study dealt with the evaluation of the histological alteration due to feeding on fried bread and the protective role of curcumin on the liver of pregnant rats and their offspring. The results showed that feeding on fried bread caused different histopathological lesions in the liver of female rats and their offspring closely similar to those induced by feeding on a diet containing acrylamide. These lesions included vacuolated cytoplasm, dilated blood vessels, congested blood vessels, haemorrhage, pyknosis, necrosis and complete degenerated areas. The emerged data showed that fried bread induced histological alterations in the liver of rats similar to those caused due to acrylamide in food. The present findings suggested that curcumin has slight protective effect against the degenerative effects of fried bread