One week eradication therapy for helicobacter pylori

ABSTRACT

1. To determine the efficacy of one week treatment in the cure of Helicobacter Pylori [H pylori] infection using triple regimen including Clarithromycin, Amoxicillin, and a Proton Pump Inhibitor [PPI]. 2. To identify the differences, if any, in response to treatment between patients from Pakistan and the rest of the world. Patients with endoscopically proven peptic ulcer disease and H pylori infection confirmed by urease test were given PPI based triple therapy for one week and then PPI was continued for another week. After two weeks, endoscopy and urease test was repeated to assess H pylori eradication. There were 32 patients [20 male, 12 female, mean age 38.9 years] included in the study. All had endoscopically proven peptic ulcer at initial diagnosis and all were positive for H pylori infection. On repeat endoscopy two weeks later, 27 patients [84.3%] showed complete ulcer healing and PPI was stopped, whereas 5 patients showed signs of partial healing. In the latter, PPI was continued for another week, and on repeat endoscopy at end of therapy, all ulcers showed complete healing. Urease test was repeated in all patients at second endoscopy and was negative in 28 patients [87.5%]. We conclude that one week of triple therapy followed by PPI for one week is sufficient for eradication of H Pylorl