Drug sensitivity pattern of salmonella thphi

ABSTRACT

To evaluate the susceptibility pattern of Salmonella typhi to different drugs in a tertiary care hospital at Karachi. Descriptive study. Clinical pathology laboratory of National Institute of Child Health, Karachi from May 2004 to June 2005. Eighty isolates of Salmonella typhi grown from blood cultures were included in the study. These isolates were identified by routine culture technique and later confirmed by slide agglutination method. Sensitivity for the following antibiotics ampicillin, chloramphenicol, cotrimoxazole, ciprofloxacin ceftriaxone and cefixime was measured by Kirby Baur method. The isolates were found to be resistant to ampicillin 52.5%, chloramphenicol 45%, cotrimoxazole 57.5%, ciprofloxacin 48.75%, ceftriaxone and cefixime 0%. Among 80 isolates, 38 [47.5%] were sensitive to first line of drugs, out of which, 11[28.94%] were resistant to ciprofloxacin. Among 80 isolates, 42 [52.5%] were resistant to first line of drugs. Out of 42 MDRS, 29[69.04%] were resistant to ciprofloxacin. It may be concluded that the trend of resistant strains of Salmonella typhi against newer drugs has reached to an alarming situation. Instead of waiting for newer drugs to come into market, we should use with care what we already have