Serum lipids and lipoproteins in chronic primary glomerular diseases

ABSTRACT

Chronic Primary Glomerular Diseases [CPGD] that are common in our country, are often neglected and not given due attention, leading rise in number of patients with renal failure. Hyperlipidemia and lipoprotein abnormalities may play role in development of glomerular atherosclerosis in renal disease. Study was designed to characterize the status of lipids and lipoproteins in patients with CPGD and to find their correlation with serum albumin and that correction of the hyperlipidemia would be favorable in solving the progress of the renal failure. Study was conducted at Biochemistry Department, Basic Medical Sciences Institute [BMSI], Jinnah Postgraduate Medical Centre [JPMC] Karachi. Seventy uncomplicated nephrotic patients [44 males, 26 females; age range 18 - 51 rears] with biopsy-proven CPGD were collected from Nephrology Department, JPMC, Karachi and twenty age- matched control subjects were investigated for serum total protein, albumin, triacylglycerols, total cholesterol, high-density lipoprotein cholesterol [HDL- cholesterol] and low-density lipoprotein cholesterol [LDL- cholesterol]. A highly significant [P<0.001] increase levels of triacylglycerols, total cholesterol, LDL- cholesterol, and the ratio of LDL-cholesterol to HDL- cholesterol, whereas a highly significant [P<0.001] decrease levels of serum HDL-cholesterol, total protein and albumin were observed in all patients when compared to matched control subjects. The correlation coefficient between serum albumin vs. triacylglycerols and total cholesterol were negative but highly significant [r = -0.68 and r = -0.64] were observed in such patients. It was concluded that CPGD are accompanied invariably by alteration in lipids and lipoproteins, which have potential for accelerating the atherosclerosis and increasing the risk of renal failure