Thyroid autoantibodies in chronic urticaria

ABSTRACT

Urticaria is characteized by the appearance of pruritic erythromatous. Itcommonly involves the trunk and extremities. Acute urticaria is a very common Clinical problem occurring in as many as 10-20% of the population Chronic urticaria Persists more than 8 weeks and may occur in individuals of any age. We evaluated thyroidautoantibodies in chronic urticaria in which allergy skin prick test was Negative and serum IgE was within normal limits. We studied antiperoxidase and antihyroglubolin antibodies in 60 patients with chronic urticaria, aged 14 to 64 years Old, 47 women [78.3%] and 13 men [23.17%], by the ELISA method. We also did CBC, ALT AST, Cr, S/E, ESR, BUN,HBSAg, Anti HCV and H. pylon antibodies,thyroid founction test that were negative. All tests were within normal limits, and 57[95%] were normal thyroid function tests. But in 22 cases [36.6%] the results of autoantibodies were as follows Antiperoxidase in 3 cases [13/6%],Antithyroglubo in 9 cases [41%],Both autoantibodies in 10 cases [45.4%],Total 22 cases [36.6%]. Sixteen patients out of 22 received 0.1mg Levothyroxin daily for 2 months. Remaining 6 patients were treated only anthistamin to serve of control group.70% out of 16 treated with Levothyroxin showed complete or partial response to treatment. This - shows that there is an association between thyroid Autoantiboies and chronic urticania. The interesting outcome of this study is that the majority of cases were Euthyroid, 57 cases [95%]