Continuous epidural infusion of midazolam for postoperative analgesia in major gynaecological surgery: comparative study with ropivacaine

ABSTRACT

The study was conducted on 60 female patients who underwent major gynaecological operations. Postoperative analgesia was managed by epidural infusion of Ropivacaine 0.2% [Group R], Midazolam 0.02% [Group M] or a combination of Ropivacaine 0.2% + Midazolam 0.02% [Group RM] in a total infusion rate of 5mL/hour for 48 hours. Visual analogue scale, respiratory rate, heart rate, blood pressure, sedation score, SPO[2], PCO[2] and blood glucose level were monitored. Results showed that group RM had significant lower VAS value and lower need for rescue analgesics. Sedation was more pronounced in RM Group than the other ones with no respiratory adverse effects. In conclusion, adding Midazolam to continuous epidural infusion of Ropivacaine provides a great analgesic and sedative effect with no side effects