Correlations between C-reactive protein as an inflammatory component of atherosclerotic process and variable lipid parameters in type 2 diabetic and hyperlipidemic patients

ABSTRACT

The study aimed to prove any correlations between CRP and different lipid parameters in patients with type 2 diabetes mellitus and hyperlipidemia. The study was conducted on 210 subjects, that were subdivided into three groups [Diabetic group, hyperlipidemic group, appearently healthy controls], each was 70 in number. Measuring of different parameters [serum concentrations of CRP, TC. HDL-C and LDL-C], were done according to standardized enzymatic assay methods. A positive correlations between CRP serum concentrations and that of TC [r = 0.37 and 0.38, P<0.05] and LDL-C [r = 0.39 and 0.35, P<0.05] respectivly in diabetic and hyperlipidemic male patients and the same results in female patients, and an inverse relationship was obtained between CRP serum levels and HDL-C serum concentrations in the diabetic and hyperlipidemic male patients, but statistically was non-significant. Serum CRP concentrations of diabetic and hyperlipidemic patients were significanty higher in both males and females than normal controls. This increase in CRP coincides a significant increase in TC, TG and LDL-C. These results may reflect that a variety of features of the metabolic syndrome are associated with a systemic inflammatory response. The higher CRP concentration in serum could reflect the inflammatory component of the atherosclerotic process that is so prelevant among patients with diabetes and hyperlipidemia