Acut organ failure in septic patients with or without shock

ABSTRACT

Sepsis and septic shock are life threatening complications of infections with a high incidence and mortality rates. Death is strongly related to types and number of systems failure, beside other risk factors. Aiming to identify the incidence of acute organ failure in relation to presence or absence of shock, retrospective evaluation was done for 170 patients admitted to Intensive Care Unit in a seven months period during 2005-2006. Patients with septic shock had a significantly higher age, APACHE II score [31.39 +/- 09.76 versus 18.6 +/- 5.73, P<0.005], SOFA score [8.42 +/- 3.70 versus 3.73 +/- 2.36, p< 0.0005], and a higher mortality rate [67.08% versus 25.27%, p< 0.0005] compared to those with severe sepsis. The percentage of acute organ failure in septic patients with shock versus those without shock was pulmonary [86.83% versus 51.65%], renal [59.49% vr 23.07%, P<0.005], hepatic [49.37% vr 25.27%, P<0.005], haematological [54.43% vr 30.77%, P<0.005] and central nervous system [13.92% vr 10.98%, P=NS] respectively. Septic shock patients were more likely to have significantly higher mean SOFA score and a higher mortality rate than non-shocked cases. Mortality increases significantly with age, APACHE II and SOFA scores