In vitro diclofenac sodium release profiles from different controlled-release matrices

ABSTRACT

In vitro release profiles were studied for the controlled- release Diclofenac sodium matrix tablets [MT2O. MT33. MT34], in comparison with Voltaren Retard r [V.R.], a well-known Diclofenac sodium enteric-coated tablet from Novartis. The percentage release of Diclofenac sodium was studied in gradient pHs [1.2, 2.1, 4.2, 5.5, 6.5, 6.7, and 7.2] in accordance with gastro-intestinal tract [git] pHs, which are varying from pH 1 to pH 8. Drug release kinetics of these formulations was also evaluated