Efficacy of intra-and post-operative peritoneal lavage in prevention of experimental postsurgical peritoneal adhesions formation in donkeys

This study was carried out on twenty two donkeys subjected to jejunal and cecal serosal stripping adhesion induction model followed by intra- and post-operative peritoneal lavage for the first three postinduction days. The chosen antiadhesivc pharmaceuticals are dimethyl sulfoxide 20% solution; sodium chloride sterile solution containing 5000 IU heparin/liter; Ringer's lactate sterile solution containing 0.1% lavasept and 1% sodium carboxymethycellulose. From the quantitative macroscopic and histopathological adhesions score system and the clinicopathological findings insignificant differences was found in the postsurgical adhesions scores among peritoneal lavaged and control groups. The effectiveness of intraperitoneal lavage using dimethyl sulfoxidc, heparin, lavasept and sodium carboxymethylcellulose in the prevention of adhesions cannot be scientifically supported because the results were controversial and lacked any implication for clinical use. No method has gained wide acceptance and surgeons must rely on meticulous surgical technique which can minimize tissue trauma and reducing the risk of postsurgical adhesions formation