Malarial antibodies and parasitaemias in immunosuppressed mice

ABSTRACT

Parasitaemia and antibody levels were followed in mice receiving cyclophosphamide [an immunosuppressive agent] and in a control group of mice, after the intraperitoneal inoculation of a standard dose of Plasmodium berghei yoelii. The drug caused impairment in both recovery from infection and antibody synthesis. In both groups of animals significant increase in antibody levels coincided with a decrease in Parasitaemia was noticed, suggesting that the humoral factor is essential in the recovery process